The usage and reputation of herbal solutions have increased globally. In fact, traditional Chinese prescription today offers a vast collection of pharmaceutical analysis, as is the case with Huperzia Serrata, a branch of the Huperziaceae species. This review describes lycopodium alkaloids separated from this plant.

However, he focused principally on Huperzine A (HupA), a likely treatment choice for various acute and chronic situations. The main healing benefit described for HupA has been the operation of dementia due to acetylcholine insufficiency, including also Alzheimer’s disease.

However, HupA has also continued shown to be useful in cerebrovascular dementia and other neurodegenerative disorders with an ischemic component, as well as other types of cognitive deterioration. HupA value has also been recorded in myasthenia gravis, organophosphate poisoning, and schizophrenia as a part of treatment.

Additionally, many other pharmacological characteristics have been assigned to HupA, particularly its newly identified anti-inflammatory, antinociceptive, and antispasmodic resources, which have made developing interest in HupA study.

Furthermore, its unique chemical structure and the fact that Huperzine A allows humans well at prescriptions far in the likeness of clinical requirements, as well as its desirable pharmacokinetics, have led to intense research in the pharmaceutical industry.

Therefore, this article examines various aspects related to Huperzine A, including not only its therapeutic attributes, but also its chemical, biological, and chemical causes, the structure-activity relation, pharmacokinetics, and toxicology, which are explained in detail in the section.

The various pharmacological results of Huperzine A have drawn much attention in science, pharmacy, and defense areas. However, the clinical advancement of Huperzine A  has been hindered by its limited supply from natural extracts.

Extraction from natural reservoirs is low-yielding (the normal dry grass yield is 0.011%), 66, and the excess of uncontrolled harvest has decimated the populations of Huperzine A. In addition, the varieties that produce Huperzine A it takes approximately 20 years within germination and majority of spores and is not sensitive to large-scale improvement.